According to Elias and a little extra

Zelous Wheeler, called up from the minors by the Yankees on Thursday when slumping Yangervis Solarte was sent down, made a big splash in his major-league debut when he hit a home run in the fifth inning against the Twins’ Phil Hughes. Wheeler is the eighth player to hit a home run for the Yankees is his first major-league game and the first since Marcus Thames in 2002. The most notable player to homer for the Yankees in his big-league debut is Yogi Berra, who did so against the Philadelphia A’s in the first game of a doubleheader in the Bronx on Sept. 22, 1946.

So how many Minnesota Twins players have hit a home run in their first game?

Rick Renick
Rick Renick
Rk Player Year ? PA AB H 2B 3B HR RBI
1 Luke Hughes 2010 Ind. Games 4 4 1 0 0 1 1
2 Andre David 1984 Ind. Games 4 4 1 0 0 1 2
3 Gary Gaetti 1981 Ind. Games 3 3 1 0 0 1 2
4 Kent Hrbek 1981 Ind. Games 5 5 2 0 0 1 2
5 Tim Laudner 1981 Ind. Games 4 3 2 0 0 1 2
6 Dave McKay 1975 Ind. Games 3 3 1 0 0 1 1
7 Eric Soderholm 1971 Ind. Games 4 2 1 0 0 1 1
8 Hal Haydel 1970 Ind. Games 3 3 2 1 0 1 1
9 Rick Renick 1968 Ind. Games 4 4 1 0 0 1 1
Provided by Baseball-Reference.com: View Play Index Tool Used
Generated 7/4/2014.

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How about if we look to see who has hit a home run in his first game when the opponent was the Minnesota Twins?

Rk Player Year ? PA AB H 2B 3B HR RBI Tm
1 Zelous Wheeler 2014 Ind. Games 4 4 2 0 0 1 1 NYY
2 Chris Richard 2000 Ind. Games 5 4 1 0 0 1 1 STL
3 Jay Bell 1986 Ind. Games 3 3 1 0 0 1 1 CLE
4 Dave Machemer 1978 Ind. Games 4 4 1 0 0 1 1 CAL
5 Bert Campaneris 1964 Ind. Games 5 4 3 0 0 2 3 KCA
6 John Kennedy 1962 Ind. Games 1 1 1 0 0 1 1 WSA
Provided by Baseball-Reference.com: View Play Index Tool Used
Generated 7/4/2014.