One player debuted in the big leagues as a Minnesota Twin on September 22.
Pete Cimino (P) – September 22, 1965 – Signed by the Washington Senators as an amateur free agent in 1960. The Twins had a 5-2 lead on the Orioles at Met Stadium when Pete Cimino came on to pitch in his first big league game. Cimino wasted no time retiring Paul Blair, Boog Powell and Brooks Robinson to secure the Twins victory.
You can check out other Major League Debuts as Twins that I have done by going here.