The only big league debut as a Minnesota Twins player on September 21.
Glen Perkins (P) – September 21, 2006 – Drafted by the Minnesota Twins in the 1st round (22nd) of the 2004 MLB June Amateur Draft. Perkins debut took place at Fenway Park in a 6-0 loss to the Red Sox as Perkins finished the game on the mound for Minnesota with 1.1 innings (18 pitches) of scoreless hitless relief with a one strike out.
You can check out other Major League Debuts as Twins that I have done by going here.