Minnesota Twins pitchers have pitched some bad games over the years, here is a list of Twins pitchers that gave up 10 or more runs in a single game. The most runs given up by a Twins pitcher was 11 by the 38-year-old Rick Reed in a 15-1 loss at the Metrodome to the New York Yankees back in 2003.
| Rk | Player | Date | Opp | Rslt | App,Dec | IP | H | R | ER | BB | SO | HR | Pit |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Rick Reed | 2003-04-21 | NYY | L 1-15 | GS-5, L | 4.1 | 10 | 11 | 10 | 3 | 4 | 2 | 95 |
| 2 | Rick Aguilera | 1996-06-11 | SEA | L 8-18 | GS-4, L | 3.0 | 10 | 10 | 9 | 1 | 0 | 1 | 70 |
| 3 | Scott Erickson | 1994-04-12 | SEA | L 0-12 | GS-4, L | 4.0 | 11 | 10 | 7 | 3 | 2 | 1 | 85 |
| 4 | Pat Mahomes | 1993-04-24 | DET | L 1-17 | GS-3, L | 2.2 | 11 | 10 | 10 | 1 | 3 | 3 | 70 |
| 5 | Willie Banks | 1992-08-04 | CHW | L 11-19 | 3-4 | 1.2 | 8 | 10 | 10 | 4 | 1 | 1 | 56 |
| 6 | Frank Viola | 1983-07-08 | CLE | L 4-10 | GS-4, L | 3.1 | 8 | 10 | 9 | 3 | 2 | 1 | |
| 7 | John Pacella | 1982-07-15 | DET | L 2-18 | 1-4 | 2.2 | 8 | 10 | 4 | 4 | 4 | 3 | |
| 8 | Geoff Zahn | 1980-07-21 (2) | BAL | L 5-12 | GS-6, L | 5.2 | 11 | 10 | 10 | 5 | 2 | 3 | |
| 9 | Joe Decker | 1976-05-12 | KCR | L 5-17 | GS-2, L | 1.0 | 8 | 10 | 10 | 3 | 2 | 0 | |
| 10 | Vic Albury | 1974-08-06 | KCR | L 3-17 | 3-7 | 5.0 | 12 | 10 | 10 | 5 | 2 | 1 |
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