Friday the 13th, June 1997. The Twins play their very first interleague game and beat the Houston Astros 8-1 in the infamous Astrodome. Chuck Knoblauch leads off the game with a single for the Twins getting their first hit and Brad Radke goes 8 innings for the win. Who hits the Minnesota Twins first interleague home run? That would be current Twins skipper Paul Molitor. Box score