April 10, 2010 – In the Twins 50 years they are 24-26 on opening day. The Twins have had 25 different pitchers take the mound on opening day on their behalf and only four pitchers have had that honor more than twice. Brad Radke was the Twins opening day pitcher 9 times including seven consecutive opening day starts. Bert Blyleven started on opening day 6 times but oddly his only home opening day start was in 1987 in the Metrodome. The only other Twins pitchers with more than two opening day starts are Frank Viola with 4 and Dave Goltz with 3.
| Year | Pitcher | Game result |
|---|---|---|
| 1961 | Pedro Ramos | Twins 6 – Yankees 0 |
| 1962 | Jack Kralick | Kansas City A’s 4 – Twins 2 |
| 1963 | Camilo Pascual | Indians 4 – Twins 4 |
| 1964 | Camilo Pascual | Twins 7 – Indians 6 |
| 1965 | Jim Kaat | Twins 5 – Yankees 4 |
| 1966 | Mudcat Grant | Twins 2 – Kansas City A’s 1 |
| 1967 | Jim Kaat | Orioles 6 – Twins 3 |
| 1968 | Dean Chance | Twins 2 – Senators 0 |
| 1969 | Tommy Hall | Royals 4 – Twins 3 |
| 1970 | Jim Perry | Twins 12 – White Sox 0 |
| 1971 | Jim Perry | Brewers 7 – Twins 2 |
| 1972 | Bert Blyleven | A’s 4 – Twins 3 |
| 1973 | Bert Blyleven | Twins 8 – A’s 3 |
| 1974 | Bert Blyleven | Twins 6 – Royals 4 |
| 1975 | Bert Blyleven | Twins 11 – Rangers 4 |
| 1976 | Bert Blyleven | Rangers 2 – Twins 1 |
| 1977 | Dave Goltz | A’s 7 – Twins 4 |
| 1978 | Dave Goltz | Mariners 3 – Twins 2 |
| 1979 | Dave Goltz | Twins 5 – A’s 3 |
| 1980 | Jerry Koosman | Twins 9 – A’s 7 |
| 1981 | Jerry Koosman | A’s 5 – Twins 1 |
| 1982 | Pete Redfern | Mariners 11 – Twins 7 |
| 1983 | Brad Havens | Tigers 11 – Twins 3 |
| 1984 | Al Williams | Tigers 8 – Twins 1 |
| 1985 | Frank Viola | Twins 6 – Angels 2 |
| 1986 | Frank Viola | Twins 3 – A’s 2 |
| 1987 | Bert Blyleven | Twins 5 – A’s 4 |
| 1988 | Frank Viola | Yankees 8 – Twins 0 |
| 1989 | Frank Viola | Yankees 4 – Twins 2 |
| 1990 | Allan Anderson | A’s 8 – Twins 3 |
| 1991 | Jack Morris | A;s 7 – Twins 2 |
| 1992 | Scott Erickson | Twins 4 – Brewers 2 |
| 1993 | Kevin Tapani | White Sox 10 – Twins 5 |
| 1994 | Kevin Tapani | Angels 8 – Twins 2 |
| 1995 | Scott Erickson | Red Sox 9 – Twins 0 |
| 1996 | Brad Radke | Twins 8 – Tigers 6 |
| 1997 | Brad Radke | Twins 7 – Tigers 5 |
| 1998 | Bob Tewksbury | Blue Jays 3 – Twins 2 |
| 1999 | Brad Radke | Twins 6 – Blue Jays 1 |
| 2000 | Brad Radke | Devil Rays 7 – Twins 0 |
| 2001 | Brad Radke | Twins 3 – igers 2 |
| 2002 | Brad Radke | Twins 8 – Royals 6 |
| 2003 | Brad Radke | Twins 3 – Tigers 1 |
| 2004 | Brad Radke | Twins 7 – Indians 4 |
| 2005 | Brad Radke | Mariners 5 – Twins 1 |
| 2006 | Johan Santana | Blue Jays 6 – Twins 3 |
| 2007 | Johan Santana | Twins 7 – Orioles 4 |
| 2008 | Livan Hernandez | Twins 3 – Angels 2 |
| 2009 | Francisco Liriano | Mariners 6 – Twins 1 |
| 2010 | Scott Baker | Angels 6 – Twins 3 |